Sentences with phrase «zebrafish with»

High - throughput imaging of adult fluorescent zebrafish with an LED fluorescence macroscope.

Close - up of muscle fibres in a zebrafish with the protein, actin, labelled with green fluorescent protein (GFP) Image credit: Elisabeth Busch, Wellcome Trust Sanger Institute

In the research, Rieger treated the zebrafish with pharmacological agents that reduce MMP - 13 activity, with the result that skin defects were improved and chemotherapy - induced nerve damage was reversed.

Importantly, treatment with the popular anti-cancer drug pazopanib tripled the survival rate of zebrafish with TB.

When he infected zebrafish with bright blue Mycobacterium marinum, he saw bright red immune cells quickly surround the bacteria to form tightly organized granulomas.

For example, male zebrafish with more numerous or more effective breeding ornaments — and thus lower regenerative potential — might contribute more to the gene pool, phasing out regenerative potential over generations.

The researchers tested the effectiveness of ECM from normal zebrafish and from zebrafish with damaged hearts, in which the ECM had already begun the healing process.

Lien and her team observed that zebrafish with a mutation at the CXCR4 receptor survive, but are not able to form coronary vessels or undergo heart regeneration following injury.

Zebrafish with very weak muscles helped scientists decode the elusive genetic mutation responsible for Native American myopathy, a rare, hereditary muscle disease that afflicts Native Americans in North Carolina.

When zebrafish with the green fluorescing endothelial gene matured, the researchers observed green FGPs on the surface of the fish's brains — confirming that these cells arose from endothelial tissue.

Building on the evidence that microglia were in play during injury, the researchers conducted tests in zebrafish with the specialized enzyme incorporated into both rod cells and microglial cells, removing both cell types to ask what role microglia play during regeneration.

If you actually read the paper that launched a thousand offbeat tidbits, by one Emmanuel Mignot of Stanford University, you discover that those «mutant» zebrafish with the defective genes were engineered to be mutants, in bulk, purely for the purpose of research.

In zebrafish with dysfunctional mitochondria, shutting down VHL nearly doubled their lifespan, Jain's team discovered.

In a special experiment, zebrafish with defective immune systems swam and dined with counterparts with normal immune systems.

For the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune system.

Not exact matches

COVER A three - dimensional micrograph of computationally separated cells with their internal organelles, as captured by a movie of the developing zebrafish eye.

Cortisol then effectively reduces levels of ACTH and CRH, completing the normal response that allows both humans and zebrafish to deal with stress.

«I can't tell you what a psychotic zebrafish looks like but I can tell you what a zebrafish treated with an antipsychotic looks like,» says Peterson.

Yanik and colleagues, who have extensive expertise with high - throughput screening in zebrafish and other small animals, have teamed up with Anderson et al., who are leading experts in RNA delivery, to create a new platform for rapidly screening biologics and methods to deliver them.

«Microbial dispersal impacts animal guts: Study with zebrafish finds that transmitted microbes will lead to similar microbiomes and a selection process for some microbes.»

And drugs with similar fingerprints tended to tweak the same molecular pathways, which suggests zebrafish behaviour is a good indicator for how a drug will change chemistry in the human brain.

«Thus, we hypothesize that Gdf3 combines with Ndr1 and Ndr2 to facilitate Nodal signaling during zebrafish development, acting as an essential factor in embryonic patterning,» said Pelliccia, a graduate student in molecular biology.

The projects are guiding research in mice, zebrafish and fruitflies, with the goal of unpicking the mechanisms of mental disorders.

Although reindeer noses aren't typically red, or infused with enough light to guide a sleigh, Farber says other earthly creatures are that color and glow through bioluminescence or fluorescence — everything from jelly fish to sea anemones to the zebrafish he studies.

Taking the example of cocaine, researchers at Eawag, together with colleagues at Zurich University, have now shown that the uptake and distribution patterns and the effects of the drug in zebrafish differ in many ways from those in mammals.

«Like zebrafish, we have this rich source of gut microbes that have figured out how to coexist with us and soothe the immune system,» she says, adding that «there is enormous potential to harness those mechanisms» to address ailments such as inflammatory bowel disease and other chronic inflammation.

By chemically removing the gut microbiome in zebrafish in the lab and then repopulating the gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications for human health.

Using a novel combination of technologies, including trio exome sequencing of patient / parental DNA and genetic studies in the tiny larvae of zebrafish, the EuroEPINOMICS RES consortium found that mutations in the gene CHD2 are responsible for a subset of epilepsy patients with symptoms similar to Dravet syndrome — a severe form of childhood epilepsy that is in many patients resistant to currently available anti-epileptic drugs.

«Now, through our new study, we show that lowering levels of a particular cohesin protein called Rad21 in embryonic zebrafish produces similar types of heart defects to those found in people with CdLS,» Associate Professor Horsfield says.

«Although zebrafish look quite different from humans, they share an astonishing 70 percent of their genetic material with humans, including genes important for the formation of new heart muscle,» Yin said.

In the case of CHD2, scientists collaborating with the EuroEPINOMICS RES consortium used antisense technology to rapidly generate zebrafish larvae with a partial loss of function of this gene, and were then able to detect epileptic seizures in these animals using electrographic analysis (this method is very similar to electroencephalography, or EEG, which is used to analyze seizures in humans).

In addition, the creation of a zebrafish model for CHD2 encephalopathy may facilitate the discovery of new drugs that can treat patients with this form of epilepsy.

Functional analyses indicate that MFSD12 encodes a lysosomal protein that affects melanogenesis in zebrafish and mice, and that mutations in melanocyte - specific regulatory regions near DDB1 / TMEM138 correlate with expression of ultraviolet response genes under selection in Eurasians.

Photo of a living Brainbow zebrafish, taken by Zachary Tobias (a research technician in Weissman - Unni's lab), showing a brightly labeled neuron with its cell body (white) at bottom.

The results from McCammon's initial screen with zebrafish indicate that two genes in the 16p11.2 region could be key for brain development: fam57ba and doc2a.

«In order to be able to research more closely what effect PSENEN has, we, in collaboration with Prof. Odermatt, deactivated the gene in some zebrafish larvae and then compared these with normal larvae under the microscope,» explains Damian Ralser.

These DNA elements have epigenetic functions that are similar in zebrafish and human melanoma and could potentially be targeted with drugs to stop a mole from becoming cancerous.

In line with the predicted incorporation and accumulation of cortisol in scales over time an experimental trial with common carp, Mozambique tilapia, and zebrafish was performed in collaboration with Prof. Dr. Gert Flik and Dr. Juriaan Metz of the Department of Animal Physiology (Radboud University Nijmegen), and Prof. Dr. Annemie Decostere of the Department of Morphology (Ghent University).

Finally, they demonstrated that zebrafish OPCs differentiate into mature oligodendrocytes when cultured together with human motor neurons, differentiated from induced pluripotent stem cells.

Using live imaging in zebrafish to track oligodendrocytes in real time, researchers reporting in the June 24 issue of the Cell Press journal Developmental Cell discovered that individual oligodendrocytes coat neurons with myelin for only five hours after they are born.

«We were very surprised to find, that for many categories of proteins, sharks share more similarities with humans than zebrafish,» Stanhope said.

It is also known that zebrafish and humans have very similar genes, and these similarities extend to more than 80 % of the genes associated with human disease.

To show their program's promise beyond plant roots, the researchers also used it with a different microscope to watch groups of cells move around in growing zebrafish (Danio rerio) embryos.

In tests on zebrafish, flies and mice, scientists found that treating the disease with purified quercetin — which targets beta - catenin — led to a significant improvement in the health of nerve and muscle cells.

A zebrafish larva is infected with Cryptococcal meningitis and photographed under a microscope.

A new study at the University of Oregon, led by postdoctoral fellow Annah Rolig, took aim at that question with experiments in zebrafish to dissect whether changes in the abundance of certain gut bacteria can cause intestinal inflammation.

In experiments with zebrafish embryos in which the expression of Abcb4 protein was suppressed, Luckenbach and his team found that the embryos were much more sensitive to toxic chemicals and that these substances were enriched to a greater extent in the embryo tissue.

Gorelick, the lead author, Halpern and Alice Hung of Carnegie, along with Luke Iwanowicz and Vicki Blazer of the Fish Health Branch of the U.S. Geological Survey, used genetically modified zebrafish that show estrogen receptor activity on a cell's DNA.

«The zebrafish model allowed us to control those variables and see how bacterial strains tracked with inflammation.

He suggests that different layers of this armor were lost in different fishes, with the dentine layer becoming the scales of sharks and skates and the bony layer becoming the scales of animals such as zebrafish.