Sentences with phrase «zebrafishes by»

Mark T. Keating and his colleagues at Harvard Medical School wounded the hearts of adult zebrafishes by surgically removing 20 percent of the muscle from the lower chamber.

Scientists established the importance of Stac3 for muscle function in zebrafish by studying the small fish physiologically and genetically.

Not exact matches

COVER A three - dimensional micrograph of computationally separated cells with their internal organelles, as captured by a movie of the developing zebrafish eye.

McGlinn will work within the supportive environment of ARMI, where 54 researchers are prying into the mysteries of vertebrate regeneration by studying sharks, mice, chickens, axolotls, and zebrafish.

«We started out by imaging zebrafish, and ended up finding a factor that makes it possible to create lymphatic cells,» says Yaniv.

For the study, the researchers created a line of zebrafish with defective immune systems by inserting a mutation into a gene required for development of an important component of the immune system.

Studies found that a derivative excreted by juiced cattle reduces minnows» fertility, transforms female zebrafish into males, and induces other masculinizing effects.

Engert, an associate professor in Harvard's Department of Molecular and Cellular Biology, studies vision and cognition by monitoring brain activity in zebrafish.

A group of researchers recently tried to settle this debate by studying the larvae of a common see - through aquarium pet, the zebrafish.

It is, however, clear that cocaine is taken up rapidly and continuously by zebrafish larvae, which at this early stage have not yet a fully developed blood - brain barrier.

A study by Eawag and Zurich University researchers using a new imaging method has revealed that, surprisingly, cocaine accumulates in the eyes of zebrafish.

Investigators at Duke University, led by Erica Davis, PhD, a co-senior author of the report, blocked the gene's expression in zebrafish, which resulted in abnormal facial cartilage, smaller eyes and structural abnormalities of neurons involved in the development of reproductive organs.

«We'll continue to investigate mechanisms by which neural tissue bridges to repair the spinal cord in zebrafish, taking advantage of the power of genome editing to examine other factors,» said Poss.

By chemically removing the gut microbiome in zebrafish in the lab and then repopulating the gut with two to three bacterial species, University of Oregon biologist Karen Guillemin has shown that certain microbes are especially skilled at suppressing the host immune system and preventing inflammation — a discovery she thinks may have implications for human health.

By contrast, zebrafish and Drosophila fruit flies lacking their versions of Lef1 are missing cells that make Corticotropin releasing hormone binding protein (Crhbp), and these cells were unaffected in mice.

If you actually read the paper that launched a thousand offbeat tidbits, by one Emmanuel Mignot of Stanford University, you discover that those «mutant» zebrafish with the defective genes were engineered to be mutants, in bulk, purely for the purpose of research.

The zebrafish research was led by Camila Esguerra of the Laboratory for Molecular Biodiscovery of University of Leuven (Leuven, Belgium).

In a study performed by North Carolina State University researchers, zebrafish that were bred to be more bold — quantified by the shorter amount of time they remained motionless when placed in new surroundings — displayed a sleeker body shape and an ability to dart around the water more quickly when startled than those bred to be more shy.

In the study, the researchers used zebrafish lines that had been selected to be bolder by breeding fish that stayed still for a maximum of 50 seconds after being introduced into new surroundings, while shy fish — those that stayed still for more than 3 minutes when dropped into a new area — were bred to create a shy line.

Photo of a living Brainbow zebrafish, taken by Zachary Tobias (a research technician in Weissman - Unni's lab), showing a brightly labeled neuron with its cell body (white) at bottom.

Researchers at Johns Hopkins Medicine report evidence that zebrafishes» natural ability to regenerate their eyes» retinal tissue can be accelerated by controlling the fishes» immune systems.

For this reason, the zebrafish is now used as a model organism by scientists around the globe.

The researchers believed that by triggering the microglia to transition from phase 1 to phase 2 more quickly by using the drug, they could improve the zebrafishes» regenerative capabilities.

The researchers hope that by harnessing the ability to improve regeneration in zebrafish, they can better understand how to induce regeneration in human eyes, which share many of the same mechanisms for controlling regenerative potential.

To test whether fatty acid levels in the bloodstream was a cause or a consequence of disease, the researchers turned to a zebrafish model of Crohn's disease that had been developed by Stefan Oehlers, a post-doctoral fellow in David Tobin's group at Duke.

Scientists led by John Kuwada, professor of molecular, cellular and developmental biology at the University of Michigan, and Hiromi Hirata of the National Institute of Genetics in Japan originally identified the gene in mutant zebrafish that exhibited severe muscle weakness.

«Our hope is that by creating this system, we can continue our own investigations into other harmful organisms, and that other scientists worldwide can adapt our zebrafish model to investigate the diseases that are priorities in their communities,» Perfect said.

Dr. Lyons and his team used zebrafish to study the formation of myelin sheaths by oligodendrocytes because this laboratory animal is transparent at early stages of its development, which allows investigators to directly observe cells within the organism.

A new study at the University of Oregon, led by postdoctoral fellow Annah Rolig, took aim at that question with experiments in zebrafish to dissect whether changes in the abundance of certain gut bacteria can cause intestinal inflammation.

Zebrafish (Danio rerio) embryos illustrating the function of the transporter protein Abcb4 acting as effective chemical defense by keeping out chemical compounds from the embryos.

The study, published Feb. 16 in PLOS Biology, made use of a mutant zebrafish strain that models human Hirschsprung disease, which is caused by loss of the gut neurons that coordinate gut contractions.

Next, the researchers gave the non-protected zebrafish an investigational drug, CLRO1, being developed by UCLA scientists that breaks up the protein aggregates, or clumps, in Parkinson's patients.

«Based on this data we concluded that the zebrafish Abcb4 protects the embryo against the toxic impact of chemicals by keeping them out,» says Luckenbach.

But research by others has shown that zebrafish scales are more related to the musculoskeletal system, rather than the tissues that form teeth.

They are aiming to reduce the number of mice used by at least 90 per cent and ultimately use zebrafish to completely replace the use of mice.

For the first time, it is now found by a study that various mechanisms of transcribing DNA into RNA exist during gene expression in the different development phases of zebrafish.

By observing the zebrafish brain activity upon presentation of the red LED they were able to visualize the process of remembering the learned avoidance behavior.

It is caused by a genetic mutation, which Dr. Baraban's group was able to introduce into the zebrafish to cause epilepsy.

By observing whole - brain activity in live zebrafish, researchers from the RIKEN Brain Science Institute have visualized for the first time how information stored as long - term memory in the cerebral cortex is processed to guide behavioral choices.

«Clinical phenotype similarity in megalencephalic leukoencephalopathy patients explained by zebrafish model study.»

«We are also exploring the possibility of using zebrafish to identify potential drugs that could alleviate pathologies caused by loss of Jagged function,» adds Dong.

In order to understand this contradiction, the research group led by Raúl Estévez and Alejandro Barrallo compared genetically - modified zebrafish and mice models — in other words, knock - out organisms that, in this case, do not express the gene MLC1 — with the brain biopsy from an MLC patient.

The study, led by Yadong Wang, the William Kepler Whiteford Professor in Bioengineering in the Swanson School of Engineering and the principal investigator of the Biomaterials Foundry at Pitt, found that a single administration of extracellular matrices (ECM) from zebrafish hearts restored the function of the heart and regenerated adult mouse heart tissues after acute myocardial infarction.

In the team's studies on zebrafish embryos, the embryos responded to a magnetic field by twirling, which they generally do in response to pressures in the water.

The mutations may also change skin color by blocking yellow pigments: When the researchers knocked out MFSD12 in zebrafish and mice, red and yellow pigments were lost, and the mice's light brown coats turned gray.

As further evidence of BMP signaling activation, proteins isolated from zebrafish embryos were examined by immunoblotting for phosphorylated Smad1 / 5.

Overexpression of R206H ACVR1 in zebrafish embryos causes strong ventralization by enhancing BMP signaling.

Inactivation of this gene in zebrafish induced retinal photoreceptor defects that were rescued by human NEK2mRNA.

«We tested a drug currently used for cancer treatment (vorinostat (Zolinza)-RRB- and found that it reduced average daily seizures in zebrafish and mouse models by 60 per cent,» says Kurrasch.

By screening commercially available drugs currently being used for other diseases, researchers found vorinostat to be an effective anti-seizure drug in zebrafish and mouse models.