Sentences with word «zidovudine»

Last August, the US Food and Drug Administration approved the drug zidovudine (AZT) for treating HIV - positive women during pregnancy.
Steve Schnittman of the NIH told a research meeting in Albuquerque that because there are now several drugs to treat HIV, studies of zidovudine alone are «not relevant in 1993».
These children typically receive zidovudine for four to six weeks after birth.
In a similar study with zidovudine, only one of 18 animals remained free of infection after six months.
When atazanavir was used with newer drugs, such as tenofovir or emtricitabine, the risk of birth defects remained higher, but there was no significant elevation in risk when atazanavir was used with older ARV drugs like zidovudine or lamivudine.
Because of the numbers of people opting for zidovudine treatment, the two groups will have become more similar over time, claims the company.
«The decision about whether to take zidovudine alone is the most important and first decision a person makes.»
Concorde set out to compare symptom - free people who started taking zidovudine immediately they were diagnosed HIV - positive with people who did not start treatment until they had symptoms of AIDS.
Discouraged by recent findings that antiviral drugs such as zidovudine (AZT), ddI and ddC are less effective than had been hoped, many people with HIV, and their doctors, are now confused about how and when to use them.
Marginal structural models to estimate the causal effect of zidovudine on the survival of HIV - positive men
Prevention of mother - to - child transmission (PMTCT) of HIV has been at the forefront of global HIV prevention efforts since 1998, following the success of the short - course zidovudine and single - dose nevirapine clinical trials in reducing transmission.
After your baby is born, she'll most likely be given an antiretroviral medicine called zidovudine (ZDV) for four to six weeks.
While zidovudine breaks down in a cell after two to three hours, PMEA persists for up to 20 hours.
Re-testing Zidovudine would require exposing some unborn children to an increased risk of HIV infection.
Once inside a T cell of the immune system, zidovudine relies on enzymes within the cell to attach phosphate groups to it before it is ready for action.
The trial was stopped when it showed that zidovudine delayed the onset of disease in the short term, and it was therefore considered unethical to continue giving people placebos.
The company says it wants to see the data re-analysed with those switched from placebo to zidovudine excluded.
Like 019 it showed that giving zidovudine early conferred some short - term advantage, but that the benefits disappeared over time.
Concorde's organisers therefore decided to allow participants with CD4 counts below this level to switch from placebo to zidovudine regardless of whether they had symptoms yet.
Whether zidovudine helps this second group has always been hotly debated.
People who took part in the trial were allocated to one of two groups: those in the first group received zidovudine (AZT) alone, while those in the second received a combination of AZT plus a drug called ddI, or AZT plus ddC.
Like zidovudine, ddI and ddC, the three existing antiviral drugs used to treat HIV, PMEA is a modified form of one of the building blocks of DNA.
The first anti-HIV drug, AZT (also known as zidovudine) was developed and approved in 1987.
One case is a clinical trial of the drug Zidovudine, a medication that was 75 percent effective in preventing HIV positive mothers from transmitting the disease to their unborn children.
If the amount of virus in the woman's body is high or unknown near the time of delivery, doctors typically order an IV of zidovudine, which passes across the placenta from a mom to her unborn baby.
Scientists randomly assigned babies of HIV - positive women to get nevirapine or nevirapine plus zidovudine (AZT).
The impetus for this clause came from the experience with the AIDS drug AZT (zidovudine).
Early work by scientists at the NIH led to the discovery that the drug AZT (zidovudine) slows the progression of AIDS.
AZT (zidovudine), the first antiretroviral drug, becomes available to treat HIV sufferers after a successful clinical trial.
Studies in monkeys have already shown PMEA to be more effective than zidovudine (AZT) in limiting infection.
Davidson says that the most popular patterns are DNA, vitamin C and zidovudine, better known as AZT.
Zidovudine was licensed for treating people with AIDS in 1987 and it clearly prolongs life for this group.
Once symptoms began, all participants were to receive zidovudine.
The participants were allocated at random to receive either zidovudine or placebo while they were well.
Most American trials of AZT (zidovudine) were stopped early for ethical reasons, so data on the drug's long - term effects have been scarce until now.
The drug, which works similarly to zidovudine (AZT) and ddI, is only for use in combination with zidovudine.
As a result, 282 of 872 symptom - free people who had been on placebo switched to zidovudine.
The AIDS programme's successes include the Concorde trial, which showed that the drug zidovudine (AZT) can not delay the onset of AIDS in HIV - positive people without symptoms, or increase their life expectancy.
Despite the short, seven - day trial, deferiprone's effect on reducing HIV blood levels was similar to a multi-week treatment with AZT, zidovudine, an antiretroviral commonly used to treat HIV.
This is in accord with our findings demonstrating a zidovudine - induced effect on nutritional parameters with zinc - adequate, but not zinc - deficient, subjects exhibiting a significant increase in the response of peripheral blood lymphocytes to mitogens (Baum et al. 1991).
Benefit of oral zinc supplementation as an adjunct to zidovudine (AZT) therapy against opportunistic infections in AIDS.
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