ZBTB48 binds through the last of its 11
zinc fingers directly to telomeric DNA (TTAGGG, in red) as well as subtelomeric variant repeats (TTGGG / TCAGGG, grey), which represent the protective caps at the end of chromosomes.
Not exact matches
In recent years several techniques, such as CRISPR / Cas9 or
zinc finger nucleases have been experimented to
directly modify the DNA of plants and animals.
Now, two independent reports of success in HD mice have given a boost to «
zinc finger» drugs - which interact
directly with the HD gene itself.