Further, zonisamide significantly decreased the wearing - off time compared with placebo (standardized mean difference, — 0.24; 95 % CI, — 0.39 to — 0.09; p = 0.001).
UPDRS Part III scores were significantly lower with zonisamide than with placebo (weighted mean difference [WMD], — 2.56; 95 % confidence interval [CI]; — 4.20 to — 0.92; p = 0.002).