Sentences with phrase «zonulin regulates»
The outer layer of your gastrointestinal (GI) tract is a film of mucus and bacteria, and a protein called zonulin regulates how tightly the cells are linked together.
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Tight junctions, regulated by a molecule called zonulin, as well as by conformational changes in the proteins occludin and claudin, are dynamic intercellular structures that modulate the trafficking or passage of macromolecules from the intestinal lumen to the submucosa and into systemic circulation (Fasano, 2012).
A research published in 2011 in the Physiological Reviews Journal stated that zonulin is the only substance that regulates the function of the tight junctions in the blood - brain barrier of brain and the intestinal barrier of the gut.
In the small intestine, gluten triggers the release of zonulin, a protein that regulates the tight junctions between epithelial cells and therefore intestinal, but also blood - brain barrier function.
It is Dr. Fasano's team discovery that «zonulin,» is the molecule which regulates intestinal permeability (also known as «leaky gut») and their totally ground - breaking research that linked an overproduction of zonulin (gluten is a clear known trigger for such in celiacs) to the development of a series of autoimmune diseases, including Type 1 diabetes, celiac disease and multiple sclerosis (at least in animals at this point in time).