The legitimacy of
zonulin testing can also be assessed by comparing it to other, well - validated methods.
Zonulin testing is not reliable for intestinal permeability and it may not even be worth testing for leaky gut
Read on to learn about the utility of
zonulin testing and other measures of intestinal permeability in clinical practice.
While it's clear that zonulin is not a reliable test for intestinal permeability, there are some alternatives to
zonulin testing:
Not exact matches
Occludin and
Zonulin: Blood
tests can measure antibodies against these two proteins, which determine brain and gut permeability.
And then there's uh — a
test by Cyrex Lab that looks at leaky gut, which could give you a predisposing marker, where it looks at
zonulin and occludin toxins which can open up the tight junctions.
Sapone et al. performed both
zonulin and lactulose — mannitol
testing and found only a very weak correlation between the results of the two assessments (correlation coefficient = 0.36)(13).
One
test that has grown rapidly in popularity is the measurement of serum or plasma
zonulin.
Some alternative practitioners also offer a blood (serum)
test for antibodies to various large molecules, including actomyosin, occludin,
zonulin, and lipopolysaccharides.