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Activating a gene called AMPK in the nervous system induces the anti-aging cellular recycling process of autophagy in both the brain and intestine, substantially prolonging the healthy lifespan of fruit flies (Image: Matthew Ulgherait / UCLA) (newatlas.com)
An additional effect of the lysosomal traffic jam is impairment in organelle and protein degradation via a lysosome - dependent pathway known as autophagy [51]. (journals.plos.org)
Daniel Papinski, shared first author of the study, explains: «In cells without these coordinators, we were able to promote waste removal by autophagy when Atg1 was artificially forced to meet the waste. (sciencedaily.com)