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When the researchers administered drugs called histone deacetylase inhibitors (HDACs)-- which promote acetylation — to mice, they had the same effect as environmental stimulation. (scientificamerican.com)
Review Publication - Mechanisms of Histone Deacetylase Inhibitor - Regulated Gene Expression in Cancer Cells (onjcancercentre.org)
«This means that patients who develop resistance to certain classes of chemotherapy can benefit from drugs that modulate histone marks such as histone deacetylase inhibitors, some of which are already approved by the Food and Drug Administration. (sciencedaily.com)