Synonyms for «major concern»

important main significant primary principal huge chief urgent big key top serious critical minor essential core public great leading national central fundamental potential common health general overall crucial foremost safety basic several grave first security utmost strong current real relevant medical specific ultimate popular vital political much growing particular

worry consideration issue problem importance trouble priority contention preoccupation matter interest attention emphasis topic threat conflict complaint discussion focus aspect fear question crisis controversy challenge conversation urgency areas point dilemma objection condition impact thing agenda reason effort people danger difficulty need struggle part constraint risk influence obstacle consequence concept