The word "myeloproliferative" refers to a condition or disease where there is an abnormal growth or production of certain blood cells in the bone marrow. Full definition
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Furthermore, mutation of the homologous Tyr931 in JAK2 wild - type or JAK2 V617F mutant found in patients with myeloproliferative neoplasms also conferred resistance to JAK inhibitors, such as INCB018424, which is currently in clinical use. (haematologica.org)
Through experiments in cell lines, primary patient samples and animal models, the research team found that SYK and FLT3 - ITD's interactions are a key ingredient in the progression of myeloproliferative disorder, a related blood cell disorder, into AML. (sciencedaily.com)
The discovery of a new therapeutic target for certain kinds of myeloproliferative disease is, without doubt, good news. (sciencedaily.com)