"Permadeath" means that once a character or player in a game dies, they cannot come back to life or be revived. It is a permanent death with no second chances. Full definition
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The game has three difficulty modes, and you can decide whether or not to play with permadeath on or off. (metacritic.com)
Hughes said they're taking inspiration from what he calls «psychological games,» titles like This War of Mine, Crusader Kings II, and Darkest Dungeon — games that all prominently feature permadeath of characters. (waypoint.vice.com)