The phrase
"serious setback" means a significant or big obstacle or problem that causes a delay or a negative impact on progress or success.
Full definition
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«serious»
«setback»
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Sentences with «serious setback»
- Initial gene therapy efforts suffered serious setbacks in the 1990s when patients in several clinical trials developed treatment - related leukemia and a young man in another trial died from his treatment. (sciencedaily.com)
- Many couples experience what feels like serious setbacks in their relationship at the onset of a child. (trisf.com)
- But I've never heard of there being a case of serious setbacks or career - ending for shoulder injuries. (sbnation.com)
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