These amazing results were also supported in test tube experiments where it was seen in human colon cells to activate a protective antioxidant response. (zestforever.com)
Cellular response to excess ROS involves the induction of antioxidant response element (ARE) genes under control of the transcriptional activator Nrf2 and the transcriptional repressor Bach1. (journals.plos.org)
During periods of oxidative stress, as levels of reactive electrophilic metabolites increase, the ability of Keap1 to target Nrf2 for ubiquitin - dependent degradation is disrupted, thereby increasing Nrf2 protein levels and its transport into the nucleus, resulting in transcription of antioxidant response genes [5], [6], [8], [10], [11]. (journals.plos.org)