«The loss or gain of multiple cancer driver genes that individually have low potency can add up to have big effects,» he said. (sciencedaily.com)
We have developed a sequencing based approach to show similar in human tissues, finding around a third of cells in normal sun exposed facial skin carry cancer driver gene mutations. (sanger.ac.uk)
Therefore, we sequenced the whole exomes of 98 HCCs from two hospitals in Taiwan and found that 78 % showed the distinctive mutational signature of AA exposure, accounting for most of the nonsilent mutations in known cancer driver genes. (stm.sciencemag.org)