Recently, clinical evidence has suggested that male dogs of certain large breeds may benefit from waiting to neuter until the dog has reached 10 - 11 months of age. (thedrakecenter.com)
Puppies: Certain large breed puppies experience growing pains. (twohandsfourpaws.com)
This inherited trait is strongly affected by lifestyle and is evident in certain large breed dogs such as the Newfoundland, German Shepherd, Saint Bernard, and the Old English Sheepdog. (darwinspet.com)