Most of the peptides are antagonists, but the peptides targeting EphA2 are agonists that activate receptor signaling and endocytosis similarly to the natural ephrin ligands. (sbpdiscovery.org)
We have identified a number of peptides that bind to Eph receptors and inhibit ephrin binding by using phage display approaches. (sbpdiscovery.org)
Yeddula N, Xia Y Ke E, Beumer J, Verma IM (2015) Screening for Tumor Suppressors: Loss of ephrin receptor A2 cooperates with oncogenic KRAS in promoting lung adenocarcinoma. (salk.edu)