A high - fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain. (completehumanperformance.com)
But insulin resistance is known to be induced, for example, by overconsumption of calories, leading to normally the liver first becoming insulin resistant and developing hepatic insulin resistance. (abcam.com)
HFD can also increase liver fat levels quite rapidly (within days) as well as hepatic insulin resistance before significant increases in peripheral fat deposition occur (23). (researchdiets.com)