The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts. (dresden-ipp.de)
Mechanistic investigations revealed that RASSF1A blocked tumor growth by stimulating cofilin / PP2A - mediated dephosphorylation of the guanine nucleotide exchange factor GEF - H1, thereby stimulating its ability to activate the antimetastatic small GTPase RhoB. (science.institut-curie.org)
In the JBC article, Lipschutz and his MUSC coauthors go a step further — showing in cell culture and a zebrafish model that depletion of Tuba, a guanine nucleotide exchange factor required for Cdc42 activation, also disrupts renal ciliogenesis. (sciencedaily.com)