The main molecular alterations are represented by variations in gene expression, usually mild and with consequences for a vast number of target protein coding genes. (mdanderson.org)
By targeting the protein made by a major disease gene, we are in a position to manipulate the key biological pathway involved in the disease. (decode.com)
The largest class of human target proteins for drugs are the so - called G - protein - coupled receptors. (sciencedaily.com)