Definition of «ectopic expression»

Ectopic expression refers to a phenomenon in which certain genes are expressed at an abnormal location or time. This can occur when regulatory elements controlling gene expression, such as enhancers and promoters, become detached from their normal genomic locations and bind to other sequences within the genome. As a result, nearby genes may be misregulated, leading to altered cellular functions and potentially contributing to disease development.

Sentences with «ectopic expression»

  • As shown in Fig. 4B, suppressive ability of miR - 7 on both transmigration through endothelial cells and Matrigel was significantly attenuated by ectopic expression of KLF4, suggesting that miR - 7 suppresses invasive ability of CSCs by blocking KLF4 expression. (cancerres.aacrjournals.org)
  • Furthermore, the growth rate is delayed by ectopic expression of DDX3 (see Fig. 1B). (cancerres.aacrjournals.org)
  • To evaluate whether KLF4 regulates the self - renewal of CSCs, we conducted fluorescence - activated cell sorting (FACS) analysis of 231BrM cells with or without ectopic expression of KLF4 followed by sorting the cells using the CSCs markers (CD24, CD44, and ESA). (cancerres.aacrjournals.org)
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