Since the reprogramming process requires only two factors, the chance of insertional mutagenesis is minimized. (journals.plos.org)
The most important intervention for insertional Achilles tendonitis is in the acute phase to stop a chronic issue and is usually treated by reducing the inflammation with rest, ice, stopping the irritation or loading issue, gentle stretches, NSAIDs (non-steroidal anti-inflammatory drugs), isometric or eccentric exercises and it is important to not poke or rub the area. (sportsinjuryclinic.net)
The earliest methods for the induction of iPSCs relied on the use of viral vectors, which are encumbered by risks of insertional mutagenesis and transgene reactivation. (stemcellres.biomedcentral.com)