Sentences with word «insertional»

Since the reprogramming process requires only two factors, the chance of insertional mutagenesis is minimized.

The most important intervention for insertional Achilles tendonitis is in the acute phase to stop a chronic issue and is usually treated by reducing the inflammation with rest, ice, stopping the irritation or loading issue, gentle stretches, NSAIDs (non-steroidal anti-inflammatory drugs), isometric or eccentric exercises and it is important to not poke or rub the area.

The earliest methods for the induction of iPSCs relied on the use of viral vectors, which are encumbered by risks of insertional mutagenesis and transgene reactivation.

The Largaespada lab has invested heavily in the use of a vertebrate - active transposon system, called Sleeping Beauty (SB), for insertional mutagenesis in mouse somatic and germline cells and for gene therapy.

Some common issues that can create painful intercourse for insertional pain are falls on your tailbone and buttocks, childbirth, and trauma from abuse, whether physical or emotional.

«There are many potential explanations for why measles virus proteins can't tolerate insertional mutations, from changing protein stability to changing the structure or function of the proteins,» Heaton says.

In a study of longevity in the adult fruit fly, Drosophila melanogaster, we found that five independent P - element insertional mutations in a single gene resulted in a near doubling of the average adult life - span without a decline in fertility or physical activity.

Channabasavaiah Gurumurthy, University of Nebraska - Easi Crispr for conditional and insertional alleles

Evaluating the Safety of Retroviral Vectors Based on Insertional Oncogene Activation and Blocked Differentiation in Cultured Thymocytes.

Largaespada's laboratory is working to exploit insertional mutagenesis for cancer gene discovery and functional genomics in the mouse.

In forward genetics, mutations can be induced by using chemical mutagens, insertional mutagens or through the delivery of diverse libraries containing, for example, cDNAs, shRNAs, or genetic suppressor elements, with each approach creating distinct genetic changes (1 — 4).

Also making sure the calf muscle can take any load and endurance of the activity with full mobility and tonicity of the muscle group when required will both help treat but also stop insertional Achilles Tendonitis from occurring.

Acute insertional tendonitis can be through repeated friction of the area and is common in athletes.

Chronic insertional Achilles tendonitis in teens is usually due to an issue like sever's disease where traction occurs at the site of insertion.

Insertional pain is a problem with the pelvic floor muscles not being able to expand and stretch open to allow the penis to enter.

Insertional Achilles tendonitis may have a lump associated with it on the calcaneum especially if an overuse or chronic injury.

«The almost complete lack of tolerance to insertional mutation of the measles proteins was surprising.

Friedrich G, Soriano P., Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cells.

Insertional mutagenesis with a single P element provides a powerful approach to obtaining mutations in silent genes when carried out in the context of whole genome sequencing.

Insertional Achilles Tendonitis is an inflammatory reaction to the tendon where it inserts into the heelbone.

The tendon is encased in a sheath and the space in between this is called the paratenon, which becomes inflamed when there is insertional Achilles tendonitis especially where it attaches into the calcaneum (heel).

Additionally, the insertional cross sectional area is also relatively small compared to the size of the muscle.

There are two types of pain with intercourse, insertional pain and deep thrusting pain.