Definition of «monoclonal»

The term "monoclonal" refers to something that is identical, or at least very similar, in all aspects. It comes from the Greek words "mono," which means single or alone, and "klonos," which means branch. In biology, monoclonal refers to a group of cells or organisms that are genetically identical because they were derived from a single ancestor cell or organism. This is in contrast to the normal process of reproduction where offspring have different genetic makeup than their parents due to random combinations of DNA during meiosis and fertilization. Monoclonal antibodies, for example, are laboratory-made molecules that can bind to specific targets on cells or tissues, and they all belong to the same "family" in terms of their structure and function.

Sentences with «monoclonal»

  • Dr. Levitsky: My organization within Roche, Pharma Research and Early Development (pRED), has invested in antibody engineering, not only for use of monoclonal antibodies in the established ways of delivering cell - killing agents to tumors or interrupting cell signalling pathways, but also as ways to engage and manipulate the immune system's response to tumors. (cancerresearch.org)
  • The Cancer Center has a history of significant advances in cancer genetics, cancer biology, tumor immunology, and virology, including the identification of genes associated with different tumor types, the development of monoclonal antibodies used to study pathways and proteins involved in tumor development, and contributions to improved cancer treatments and diagnostic tests. (wistar.org)
  • Crowe and his colleagues have developed a method for rapidly producing large quantities of human monoclonal antibodies against specific viral targets. (sciencedaily.com)
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