Senescent refers to something that is growing old or declining in strength, vitality, or function. It can also describe a state of being past one's prime or experiencing a gradual loss of ability due to age.
«Osteoarthritis has previously been associated with the accumulation of senescent cells in or near the joints, however, this is the first time there has been evidence of a causal link,» says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging. (sciencedaily.com)
Certainly we can talk about cancer risk, and we can talk about rising numbers of cells becoming senescent in response to DNA damage, and researchers can disable DNA repair to observe the shortened life spans that result from such a fundamental breakage in cellular operation, but beyond that it becomes increasingly challenging to quantify effects within the scope of normal degenerative aging. (fightaging.org)
They showed that rapamycin reduced the secretion of inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR pathway, which promotes growth. (sciencedaily.com)