Sentences with word «senescent»

«Osteoarthritis has previously been associated with the accumulation of senescent cells in or near the joints, however, this is the first time there has been evidence of a causal link,» says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging.

Certainly we can talk about cancer risk, and we can talk about rising numbers of cells becoming senescent in response to DNA damage, and researchers can disable DNA repair to observe the shortened life spans that result from such a fundamental breakage in cellular operation, but beyond that it becomes increasingly challenging to quantify effects within the scope of normal degenerative aging.

They showed that rapamycin reduced the secretion of inflammatory cytokines from senescent cells in culture and in mice by suppressing the mTOR pathway, which promotes growth.

Studies over the course of the last decade have revealed the somewhat surprising fact that the body's immune system routinely eliminates senescent cells from our tissues.

Then I wonder whether we'd get a better idea by clearing senescent cells in mice that receive the same medical care (anti-cancer etc) as humans.

And there are reasons to believe that the resulting arrest of multiple aspects of tissue aging by removal of p16Ink4a - expressing senescent cells would indeed translate into the tissues of genetically - intact mice — or humans.

By selectively killing senescent cells — ones that no longer grow or divide — Baker impeded the onset of cataracts, weakening of muscles, and body fat loss.

«Our method allowed us to look at the consequences of removing senescent cells at different stages of the mouse life cycle,» van Deursen says.

Thus, large, old trees do not act simply as senescent carbon reservoirs but actively fix large amounts of carbon compared to smaller trees; at the extreme, a single big tree can add the same amount of carbon to the forest within a year as is contained in an entire mid-sized tree.

Sophisticated cell targeting systems such as the gene therapy approach developed for senescent cell clearance by Oisin Biotechnologies could also be turned to stem cell or immune cell destruction, given suitable markers of cell chemistry.

Oisín Biotechnology — a startup with initial funding from SENS Research Foundation, the Methuselah Foundation, and others — is close behind them, having developed a form of gene therapy that — in animals at least — also destroys these cells, using an approach that is less inherently likely to destroy healthy cells along with senescent ones.

At an earlier stage, Julie Andersen, PhD and coworkers at the Buck Institute have reported that destroying senescent inflammatory cells in the brains of animals substantially protects them against paraquat, a toxin that causes a PD - like syndrome in mice and humans alike by selectively killing dopamine - producing neurons in the brain.

«The inescapable conclusion is these birds were not senescent, not in the old age of their lineage and about to exit from the world.

She is widely recognized for her work on senescent cells — older cells that have stopped dividing — and their influence on aging and cancer.

Mice from which senescent cells have been removed had increased median life span and improved health, researchers reported in Nature in February (SN: 3/5/16, p. 8).

Cellular zombies called senescent cells are stressed cells that have entered a type of stasis — they're not dead, but they're not functioning either.

This paper confirms loads of previous research that increased senescent cell accumulation through aging has a direct effect on quality of life.

At the 2016 International Cell Senescence Association Conference, Dr. Andrei Gudkov, CSO of Everon, explains why senescent cells may not be the only drug target for anti-aging therapies

But Campisi also made clear the new findings about senescent cells may signal a regime shift in aging research because if proven true, huge gains could be made in living healthfully as our clocks run out.

As a postdoctoral researcher at Harvard Medical School, he investigated the use of small - molecule drugs to manipulate signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

As a postdoctoral researcher at Harvard Medical School, he investigated manipulation of signaling pathways to enable otherwise senescent progenitor cells of the cochlea to divide and form new sensory cells.

Something that breaks glucosepane cross links in a significant amount of tissue or something that removes most senescent cells from an organism.

The funds will help the clinic establish laboratories to study senescent cells, which seem to accumulate in our bodies with age.

Although senescent cells no longer divide, they...

Senescent intimal foam cells are deleterious at all stages of atherosclerosis.

But for reasons that are not fully known, as we age, persistently senescent cells accumulate, leading to a vast number of age - related diseases.

The researchers first took blood samples from each of the volunteers to examine how many senescent and naïve T cells each had.

«Researchers link senescent cells to most common form of arthritis.»

Darling had just pitched 3 «Äö √ Ñ √ ∂ «àö √ ± «àö ¬ ® innings in Tampa against the Reds, and now, weaving through cars driven by suntanned and senescent drivers, he excitedly bounded from thought to thought, from Bernie Carbo to No «Äö √ † √ ∂ ¬ ¨ ¬ • l Coward.

Without this crucial process, cells would eventually fall into a zombielike senescent state (see «More Than a Sum of Our Cells», «How a clk Ticks», and «Short and Solid»).

«We investigated whether the presence of senescent telomere fragments in the amniotic fluid around the fetus is linked with labor status, as we know that the telomeres continue to get shorter as the pregnancy progresses,» Menon said.