The phrase "significant changes" means important or noticeable alterations, modifications or transformations. It refers to any notable shifts or adjustments that have a substantial impact on something. These could be positive or negative and can affect various aspects such as behavior, circumstances, conditions, policies, relationships, situations, systems, etc. The term is often used in relation to events, trends, developments, or decisions that bring about noticeable differences or alterations in the way things are done or experienced.