The phrase "significant changes" refers to important and noticeable alterations or modifications that have a considerable impact or importance. Full definition
I think the message you are saying here is that people need to take action to support themselves in making significant changes in their relationships. (drmichellegannon.com)
The learning that I did in this class strongly supported my ability to make a number of significant changes in how I address my sense of wellness. (wellpeople.com)
The market continues to adjust to the most significant changes in over three decades after tax reform passed. (hartfordfunds.com)