(A) A low concentration of FBS in combination with a high concentration of recombinant Activin A could induce iPS cells of line 11.1 into a definitive endoderm lineage. (journals.plos.org)
In 2006, Penn researchers led by Kaplan and Eileen Shore, PhD, the Cali - Weldon Professor of FOP Research and a co-author on the current study, discovered how a mutation in the gene for a BMP receptor called Activin Receptor A type I (ACVR1) occurs in all individuals who have classic FOP. (sciencedaily.com)
The study found that by manipulating the activity of Activin receptors — receptors found in the brain — the researchers were able to increase or decrease cocaine - taking and relapse behavior in animal models. (sciencedaily.com)