Luster's team hopes to further investigate the characteristics of joints that underlie the critical role of C5a in initiating type III hypersensitivity and whether specific molecules expressed on endothelial cells lining joints play a role in transporting C5a and chemokines from the joint space into adjacent blood vessels. (sciencedaily.com)
Current thinking regarding type III hypersensitivity is that immune cells within tissues sense the presence of these immune complexes (ICs) through specific receptor molecules and release inflammatory factors called cytokines that activate the endothelial cells lining adjacent blood vessels to promote the recruitment of neutrophils. (sciencedaily.com)
Human glomerular podocytes further matured around adjacent blood vessels as in a living body (image 1) and formed a characteristic filtration membrane structure.. (sciencedaily.com)