The increase, observed as early as 60 seconds after the addition of corticotropin - releasing factor, suggests that changes in the intracellular concentration of the cyclic nucleotide coincide with or precede the secretion of adrenocorticotropic hormone in response to corticotropin - releasing factor. (science.sciencemag.org)
In the normal response to a stressful situation, the hypothalamus in the brain sends corticotropin - releasing hormone (CRH) to the pituitary gland, which releases adrenocorticotropic hormone (ACTH) to the adrenal gland. (scientificamerican.com)
Both the canine and human diseases have similar clinical presentation, with the diagnosis based on performing a dynamic adrenocorticotropic hormone stimulation test. (link.springer.com)