Exploiting this compartmentalization, the team developed an endosomally - targeted β - secretase inhibitor that specifically blocked cleavage of amyloid precursor protein but not non-amyloid proteins. (sciencedaily.com)
In 2014, Anna earned her Ph.D. in Cell & Molecular Biology at Drexel University where she focused on characterizing Sonic Hedgehog signaling pathway and its role in Amyloid Precursor Protein (APP) processing, Amyloid - beta clearance, and trafficking to primary cilia. (klannlabnyu.org)
Specifically, rodents genetically modified to express human amyloid precursor protein (hAPP), which can lead to the debilitating plaques that form in the brains of Alzheimer's patients, seem to struggle to find the hidden platform relative to their healthy peers. (sciencemag.org)