In animal infection models using these pathogens, IL - 22 primarily plays a protective role by maintaining barrier integrity and thereby limiting bacterial dissemination. (journals.plos.org)
Animal infection experiments were conducted under the protolcol (CAU - AEC -2010-0603) approved by the China Agricultural University Animal Ethics Committee. (journals.plos.org)
The mutant strep bacteria also lost the ability to produce severe disease in animal infection models (sciencedaily.com)