My Kindle Voyage continues the same layout and having a narrow bezel, presents very little to clamp between base of thumb and fingertips of one hand alone. (goodereader.com)
Use a tightly rolled hand towel to put under your palms by the base of your thumb to set your palms in a more comfortable angle. (spinningbabies.com)
In an analysis of the remarkably complete hands, paleoanthropologist Tracy Kivell of the University of Kent in the United Kingdom found that bones in the wrist were shaped like those in modern humans, suggesting that the palm at the base of the thumb was quite stiff. (sciencemag.org)