This assay will increase the probability of identifying T cell receptor beta chain gene rearrangements versus when testing for TRG gene rearrangements only. (invivoscribe.com)
As the name implies, Vα14 iNKT cells express a TCR with extremely limited diversity, consisting in mice of an invariant alpha chain (Vα14 - Jα18) generally paired with beta chains using Vβ8.2, 7 or 2. (lji.org)
Since genes for the T - cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig - like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B - cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. (science.sciencemag.org)