«There's a lot of troubleshooting that needs to be done to get it to be accurate enough to be able to compete with bisulphite sequencing.» (scientificamerican.com)
These individuals had already been deep sequenced with Illumina technology, both for variant calling and estimation of DNA methylation based on treatment with bisulphite. (nanoporetech.com)
The gold - standard method for detecting DNA methylation, which Clark's group developed more than 15 years ago, is bisulphite sequencing, in which unmethylated versions of the base cytosine are chemically converted into another base, uracil. (scientificamerican.com)