A high blood bilirubin level may result from red blood cell destruction. (en.wikipedia.org)
The three main classes include excessive blood loss (acutely such as a hemorrhage or chronically through low - volume loss), excessive blood cell destruction (hemolysis) or deficient red blood cell production (ineffective hematopoiesis).» (religion.blogs.cnn.com)
Splenectomy is done in resistant cases since it is a major site of red blood cell destruction. (vetinfo.com)