"Bone cancer" refers to a type of cancer that starts in the bones. It occurs when cells in the bones grow and divide abnormally, forming a mass or tumor. Full definition
Body size and sex are also important in the development of bone cancers in dogs so genetic factors also have a role. (brittonroadveterinaryclinic.com)
We also see a fair amount of bone cancer in dogs. (pets.webmd.com)
According to a study that was conducted in 1979, the risk of a dog developing bone cancer increases by 60 to 185 times in breeds that are larger than 80 pounds. (thehappypuppysite.com)