Moreover, three - dimensional (3D) μCT reconstruction of the tibia revealed that mice injected with control cells had a significantly higher degree of osteolysis with a decreased ratio of bone volume to total volume compared to mice injected with ABL1 / ABL2 knockdown breast cancer cells (Fig. 4, E and F). (stke.sciencemag.org)
When mice were injected with irisin or viruses engineered to express irisin, the team found significant increases in bone volume and thickness compared to mice treated with saline. (sciencedaily.com)
Example of longitudinal changes in cortical bone volume fraction (BV / TV) and cortical thickness (Cr.Th) for Sham - operated and Ovarectomized OVX groups. (ics-mci.fr)