Finally, to determine whether LARP7 KD also results in an increase in breast cancer metastasis in vivo, the T47D control or shLARP7 - 2 cells were injected intravenously into the nude mice, and lung metastasis was examined 12 weeks later. (elifesciences.org)
The alpha2 beta1 integrin: a regulator of breast cancer metastasis. (vicc.org)
These data, together with the finding that knockdown of both TAZ and STAT5 phenocopied the decrease in breast cancer cell metastasis caused by ABL1 / ABL2 depletion, supports a model for a requirement of ABL - dependent TAZ and STAT5 signaling networks in promoting breast cancer metastasis (Fig. 8B). (stke.sciencemag.org)