The researchers performed a series of experiments with breast cancer samples and mouse models of breast cancer. (sciencedaily.com)
Although the differing effects of hypoxia reported here are in conflict with previously published data, where no contrasting effect was seen (18 — 20), our data was produced using 13 primary breast cancer samples, as well as established cell lines, and the opposing effects in hormone receptor — positive and negative tumors, measured using multiple in vitro and in vivo CSC assays, were consistent in all cases. (cancerres.aacrjournals.org)
«These findings,» the authors note, «emphasize the clinical value of assessing both progesterone receptor and estrogen receptor expression in breast cancer samples.» (uchospitals.edu)