Projects restricted to the creation of conventional mouse knockouts in candidate disease genes identified by association studies, or to broadly overexpress those genes, are discouraged. (mcknight.org)
Although hundreds of thousands of samples have been sequenced, our ability to find, associate, and implicate genetic variants and candidate disease genes far outstrips our ability to understand them. (sciencemag.org)
«Our research team is the first to describe a high - throughput in vivo validation system to screen candidate disease genes identified from patients. (sciencedaily.com)