Specifically, the data reveal distinct transitions in factors that influence the different cellular states including cell cycle regulators, transcription factors, and signaling factors. (sciencedaily.com)
Recently, several RNA helicases, such as RNA helicase A and CHAMP, have been shown to modulate the expression of cell cycle regulator p16INK4a or p21waf1 / cip1 (32, 33). (cancerres.aacrjournals.org)
Its major target genes include proapoptotic genes Bax, Puma and Noxa, cell cycle regulator p21, and the senescence - inducing gene Plasminogen activator inhibitor 1 [5]. (oncotarget.com)