Over time, the damage to the tissues and organs accumulates and the pace of cellular mutations accelerates, eventually reaching a point where the body can't repair or dispose of damaged cells fast enough. (strengthtrainingendeavors.com)
Secondly, before considering the use of iPSC - derived organoids for transplantation / regenerative medicine in human patients, the current protocols for expansion, reprogramming and differentiation of iPSCs in long - term cultures need further improvement to minimize the risk of oncogenic cellular mutations and teratoma, or tumor formation, in the patient. (mdibl.org)
Afatoxin - B1 is metabolized to a carcinogen that induces cellular mutations which lead to increased risk of developing liver cancer and hepatocellular carcinoma. (alivebynature.com)