Due to the «masked affected» phenomenon, in which the developing tapetum pigmentation obscures areas of choroidal hypoplasia, it is vital that all puppies be checked at a young age, certainly no later than 8 weeks, preferably sooner. (ashgi.org)
The U.S. registration organization, CERF, reported the incidence in the U.S. of choroidal hypoplasia, optic disc / nerve coloboma and retinal detachment among several affected breeds over the period of 1991 to 1999. (optigen.com)
Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator of actin cytoskeleton dynamics (i.e. the inner structural support of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel growth), inflammation, and fibrosis (thickening and scarring of tissue) associated with choroidal neovascularization (CNV) in wet AMD. (brightfocus.org)