The experiments were performed in mice with chronic viral infections, the system in which T cell exhaustion and PD - 1's immune - braking function were first discovered. (sciencedaily.com)
In the face of chronic viral infections such as hepatitis and HIV as well as certain types of cancers, CD8 T cells become less effective over time until they ignore calls to arm. (sciencedaily.com)
In chronic Lyme and associated diseases Olive Leaf Extract (OLE) is an antimicrobial for acute viruses, like the cold and flu viruses, and chronic viral infections like Human Herpes Virus 6 (HHV - 6), Cytomegalovirus (CMV), and Epstein Barr Virus (EBV). (treatlyme.net)