The mechanism of peptide bond synthesis appears to resemble the reverse of the acylation step in serine proteases, with the base of A2486 (A2451 in Escherichia coli) playing the same general base role as histidine - 57 in chymotrypsin. (science.sciencemag.org)
The two common genetic mutations found in the group with early - onset pancreatitis were cationic trypsinogen (PRSS1) and chymotrypsin C (CTRC). (sciencedaily.com)
Klegeris, A. and McGeer, P.L. Chymotrypsin - like proteases contribute to human monocytic THP - 1 cell, as well as microglial neurotoxicity. (mcgeerandassociates.ca)