We want to understand how different RFX transcription factors are required for ciliogenesis control and how they are involved in ciliary specialization in mouse tissues. (inmg.fr)
Depletion of dynamin - binding protein or Tuba, a guanine nucleotide exchange factor, disrupted renal ciliogenesis in cell culture and led to abnormal kidney morphology in a Tuba knockdown zebrafish model of PKD. (sciencedaily.com)
Once the pathways underlying impaired ciliogenesis in PKD are more fully understood, therapeutic interventions can be designed to disrupt those pathways. (sciencedaily.com)