Estrogens have been reported to exert protective vascular effects in animal and observational but randomized clinical trials did not report such effects in older women, even suggesting the possibility of an increased CVD risk in this setting, especially with combined estrogen plus progestin therapy. (sciencedaily.com)
«Relatively short - term combined estrogen plus progestin use increases incident breast cancers, which are diagnosed at a more advanced stage compared with placebo use, and also substantially increases the percentage of women with abnormal mammograms. (jeffreydachmd.com)
Even pills that combined estrogen with other hormones meant to alleviate those problems didn't fare any better when it came to dangerous side effects. (sciencemag.org)