When a rewarding choice has been made, the substantia nigra pars compacta (SNc) releases dopamine into the striatum to reinforce connections between cortex and striatum, so that rewarded actions are more likely to be repeated. (sciencedaily.com)
As was mentioned in the beginning of this monograph, Parkinson's disease essentially involves dysfunction of the DA neurons in the pars compacta region of the midbrain of the substantia nigra. (mossnutrition.com)
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